Virus del papiloma humano (VPH): microbiología, relación con el cáncer de pene y características de la vacuna

Título

Description

El Virus del Papiloma Humano (VPH) ha sido en las últimas 2 décadas un objeto importante de estudio por su relación causal en el cáncer de cérvix y su asociación como factor de riesgo en neoplasias anogenitales, en especial el cáncer de pene (CaPe). El estudio molecular del VPH y la identificación de proteínas esenciales ha permitido el desarrollo de la vacuna. Además, se identifica una relación epidemiológica clara entre el VPH y el CaPe. En el aspecto molecular de esta relación, es clara la alteración de la vía del P16 celular por las oncoproteínas del virus, aunque se cree que no es el único mecanismo de patogenia. En cuanto a la vacuna, se sugiere efectividad en la prevención contra infección del VPH en hombres, aunque no hay evidencia suficiente para aseverar la protección contra CaPe. Teniendo en cuenta lo anterior, se abre una brecha de investigación, tanto en el área clínica, para tratar de establecer la efectividad-eficacia de la vacuna en la prevención CaPe, como el de la biología molecular en el estudio de los mecanismos moleculares en la patogenia de esta neoplasia.

Relation

Grupo de Ciencias Odontológicas Unicoc

Creator

Osorio Patiño, Julio Cesar

Rengifo-Rodríguez, Javier Eduardo

García-Perdomo, Herney Andrés

Mediator

Centro de Investigación Colegio Odontológico - CICO

Date Issued

2020-08-11

Abstract

Over the past two decades, human papillomavirus (HPV) has been an important object of study due to its causal relation to cervical cancer and its association as a risk factor for anogenital neoplasias, especially penile cancer (PC). The molecular study of HPV and the identification of essential proteins led to the development of the vaccine, and a clear epidemiologic relation between HPV and PC has also been identified. With respect to the molecular aspect of that association, the alteration of the P16 cellular pathway by the oncoproteins of the virus is evident, but it is not thought to be the only pathogenic mechanism. The vaccine appears to be effective in preventing HPV infection but there is not sufficient evidence that it protects against PC. Therefore, more research is needed, both in the clinical area, to determine whether the vaccine is definitively effective/efficacious in the prevention of PC, and in molecular biology, studying the molecular mechanisms involved in the pathogeny of that neoplasia.

Extent

10 pp.

Format

application/pdf

doi

https://doi.org/10.48193/revistamexicanadeurologa.v80i4.536

issn

2007-4085

0185-4542

Lenguaje

Español

Publisher

Sociedad Mexicana de Urología

page end

10

issue

4

page start

1

Fuente

Revista Mexicana de Urología

Revista Mexicana de Urología (RUM)

Repositorio Institucional Unicoc - RI-Unicoc

volume

80

Is Part Of

Revista Mexicana de Urología (RMU), ISSN: 0185-4542; ISSN: 2007-4085, Vol. 80, No. 1, (Julio-Agosto 2020); pp. 1-10

uri

https://revistamexicanadeurologia.org.mx/index.php/rmu/article/view/536

Access Rights

openAccess

Bibliographic Citation

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primary topic

Research Subject Categories::ODONTOLOGY::Odontological behavioural science

Subject

Human papillomavirus

Review article

Penile cancer

Vaccine

Carcinogenesis

Virus del papiloma humano

Cáncer de pene

Vacuna

Carcinogénesis

Artículos de revisión

Alternative Title

Human papillomavirus: Microbiology, association with penile cancer, and characteristics of the vaccine

Tipo

Artículo

current project

Grupo de Ciencias Odontológicas Unicoc

number of pages

10 pp.

Identifier

https://revistamexicanadeurologia.org.mx/index.php/rmu/article/view/536

Elemento